Pharmacological properties equipoise for horses ® – antimicrobial topical application helps to heal wounds (burns, trophic, purulent, etc.), provides effective protection from infection of wounds, reduce the time of treatment and the preparation of a wound to skin grafts, in many cases, leads to improvement state, eliminates the need for transplantation.
part of the cream sulfanilamide – sulfathiazole silver is bacteriostatic antimicrobial agent with broad antibacterial bacteriostatic action against Gram-positive and Gram-negative bacteria. The mechanism of antimicrobial action sulfathiazole -ugnetenie growth and reproduction of bacteria associated with a competitive antagonism with para-aminobenzoic acid and digidropteroatsintetazy suppression that leads to disruption of the synthesis of dihydrofolic acid and eventually its active metabolite – tetrahydrofolic acid required for the synthesis of purines and pyrimidines microbial cells. Present in the preparation of silver ions enhance antibacterial sulfanilamide – they inhibit the growth and division of bacteria by binding of deoxyribonucleic acid with microbial cells. In addition, the silver ions weaken the sensitizing properties of sulfanilamide.
Due to the minimal resorption of the drug it has no toxic effect.
Contained in the preparation of silver sulfathiazole, has little solubility, whereby after topical application concentration of the active substance in wound continuously maintained at the same level. Only a small amount of silver sulfathiazole appears in the bloodstream, and then subjected to acetylation in the liver.
The urine is in the form of active metabolites and partly in an unmodified form. Absorption of silver sulfathiazole increases after application to extensive wound surfaces.
- Burns of varying degree, of any nature (thermal, solar, chemical, electric current, radiation, etc.); frostbite.
- bedsores; leg sores of different genesis (including at chronic venous insufficiency, occlusive disease, blood circulation disorders in diabetes, erysipelas, etc.);
- Festering wounds; small household injuries (cuts, abrasions);
- Infected dermatitis, impetigo, a simple contact dermatitis, microbial eczema; streptostafilodermii.
- Hypersensitivity to sulfathiazole and other sulfonamides.
- Congenital deficiency of glucose-6-phosphate dehydrogenase.
- Prematurity, infants under 2 months (the risk of “nuclear” jaundice).
Pregnancy and lactation
Application equipoise for horses ® during pregnancy and breast-feeding is permitted in cases where the surface of the burn does not exceed 20% of the body surface and the potential benefit to the mother to assess physician prevails over potential risk to the fetus and child.
Dosing and Administration
External -. Both open pit and under occlusive dressings
after cleansing and debridement of the wound is applied to the drug under sterile conditions and the thickness of 2-3 mm 2-3 times a day. The wound during treatment should be completely covered with cream. If part of the wound open, you must also put the cream. Imposition of occlusive dressings – is possible, but is not mandatory.
The cream is applied to the complete healing of wounds or until skin grafting. In the case of the drug exudate may appear on infected wounds. Before applying the cream should be washed wound 0.1% aqueous solution of chlorhexidine or other antiseptic.
The maximum daily dose – ’25
The maximum duration of treatment – 60 days.
Allericheskie reactions, local reactions (burning, itching, redness of the skin). Prolonged use may leukopenia, deskvamatozny dermatitis.
Cases of overdose are not logged in.
Interaction with other medicinal products
is not recommended to be used in conjunction with other topical medications. Folic acid and its structural analogs are able to weaken the antimicrobial action sulfathiazole.
In hepatic and / or renal failure is necessary to control the concentration of serum sulfathiazole.
Caution should be exercised when used in patients in shock condition with extensive burns, due to the inability to collect full allergic history.
The effect on vehicles and machinery handling ability
drug does not limit the ability of the mind-body, the ability of road management and maintenance machinery in motion.
Cream for external use 2%.
In 15 g and 40 g in aluminum, inside lacquered lithographed tubes.
In 400 g in boxes made of polypropylene (for hospitals).
1 tube with instruction on use is placed in a cardboard box.
In 10 boxes polypropylene together with instructions for use on the number of boxes placed in a shipping carton (for hospitals).