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Antiviral agent. Specifically inhibits influenza viruses A and B, coronavirus associated with severe acute respiratory syndrome (SARS).According to the mechanism of the antiviral action relates to fusion inhibitors (fusion), interacts with hemagglutinin of the virus and prevent fusion of the lipid envelope of the virus and cell membranes. It provides moderate immunomodulatory effects. Interferon has activity stimulates humoral and cellular immune responses, phagocytic function of macrophages, increases resistance to viral infections. It reduces the incidence of complications associated with viral infection and exacerbations of chronic bacterial diseases.
The therapeutic efficacy in viral infections manifested in reducing the severity of intoxication and clinical effects, reducing the duration of the disease, reducing the risk of complications.
It belongs to low-toxic drugs (LD50> 4 g / kg). It does not appear to have any adverse effects on the human body when administered orally in the recommended dosages.

Pharmacokinetics . Rapidly absorbed and distributed to organs and tissues. The maximum plasma concentration at admission in a dose of 50 mg is achieved in 1.2 hours, in a dose of 100 mg – 1.5 hours is metabolized in the liver.. The half-life is 17 – 21 hours, about 40% is excreted in unchanged form, mostly in the bile (38.9%) and traces of the kidneys (0.12%).. During the first day shows 90% of the administered dose.

Indications

Prevention and treatment in adults and children:
– influenza A and B, SARS, severe acute respiratory syndrome (SARS) (including complicated by bronchitis, pneumonia);
– secondary immunodeficiency states;
– complex therapy of chronic bronchitis, pneumonia, and recurrent herpetic infection.
Prevention of postoperative infectious complications and the normalization of immune status.
Combined therapy of acute intestinal infection rotavirus etiology in children older than 3 years.

Contraindications

Hypersensitivity to the drug, children under 3 years.

Dosing and Administration

Inside, before meals. Single dose: children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, over 12 years and adults – 200 mg (2 tablets of 100 mg or 4 tablets of 50 mg).

For nonspecific prevention: – by direct contact with patients with influenza and other acute respiratory viral infection: children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, over 12 years and adults – 200 mg 1 time a day for 10 – 14 days – during epidemics of influenza and other acute respiratory viral infections, for the prevention of exacerbations of chronic bronchitis, recurrent herpetic infection: children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, over 12 years and adults – 200 mg 2 once a week for 3 weeks. – for the prevention of SARS (in contact with the patient): adults and children over 12 years prescribed 200 mg once a day for 12-14 days. – prevention of postoperative complications: children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, over 12 years and adults – 200 mg for 2 days prior to surgery, and then for 2-5 days after surgery.

For the treatment of: – the flu and other acute respiratory viral infections without complications: children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, over 12 years and adults – 200 mg 4 times a day (every 6 hours) for 5 days influenza and other acute respiratory viral infections with the development of complications (bronchitis, pneumonia, and OE): children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, over 12 years and adults – 200 mg 4 times a day (every 6 hours) for 5 days, followed by a single dose of 1 times a week for 4 weeks. Severe acute respiratory syndrome (SARS): adults and children over 12 years – 200 mg 2 times a day for 8-10 days. in the complex treatment of chronic bronchitis, herpetic infection: children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, over 12 years and adults – 200 mg 4 times a day (every 6 hours) for 5-7 . days, then a single dose of 2 times a week for 4 weeks Combined therapy of acute intestinal infection rotavirus etiology in children older than 3 years: from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, over 12 years – 200 mg four times a day (every 6 hours) for 5 days.

Side effect

Rarely – allergic reactions.

Overdose

Not marked.

Interaction with other drugs

In the appointment of other drugs adverse effects were noted.

special instructions

It does not show the central neurotropic activity and can be used in medical practice as a preventive measure in healthy persons of various professions, including requiring attention and coordination of movements (transport drivers, operators, etc.).

release Form

Tablets, film-coated 50mg, 100mg.
10 tablets in blisters.
At 10, 20, 30 or 40 tablets bank polymer.
1, 2, 3 or 4 blisters or bank polymer 10, 20, 30 or 40 tablets, together with instructions for use in a stack of cardboard. how much to inject for weight loss

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