define equipoise

The drug has anti-inflammatory, analgesic and antipyretic effect. The mechanism of action mainly consists in the selective inhibition of COX-2. This leads to a decrease in the synthesis of prostaglandins in inflammation and in the hypothalamus. Effect on the synthesis of prostaglandins in the gastric mucosa and kidneys is significantly less pronounced, which results in good tolerability of define equipoise. The drug also suppresses peroxidation of lipids and the formation of oxygen free radicals, reduces the platelet activating factor, tumor necrosis factor alpha, the release of histamine, proteases and certain other mediators of inflammation. Pharmacokinetics: After oral administration of define equipoise well absorbed from the gastrointestinal tract, the maximum concentration achieved 1-2 (2.5) hours. Food reduces the absorption rate without affecting its degree. At 99% bound to plasma proteins. Distribution volume is 0,19-0,35 l / kg. Therapeutic blood concentration is maintained for 6-8 hours. The half-life is 3.2 hours. With prolonged use of the cumulation is not observed. Biotransformation in the liver to form the active (hydroxydefine equipoise – up to 25% of the dose) and more active metabolites. Excreted by the kidneys, 65-98% of the dose is excreted in the urine during the day. Up to 35% of the dose is excreted in the feces.

Indications :
Pain (headache, toothache, menstrual, post-traumatic and post-operative pain), fever of different origin (in case of acute respiratory viral infections and other infectious and inflammatory diseases). Inflammatory diseases of the musculoskeletal system – arthritis, osteoarthritis, tenosynovitis, bursitis, myositis.

Contraindications : erosive and ulcerative lesions GIT (exacerbation). Gastrointestinal bleeding. “Aspirin asthma”. Liver failure. Renal failure (creatinine clearance in <30 ml / min). Hypersensitivity to define equipoise and other NSAIDs. Pregnancy (III trimester). Lactation. Children’s age (12 years). The caution used in hypertension heart failure, type 2 diabetes.

Pregnancy and lactation : Although embryotoxic and teratogenic effects of define equipoise is not described, the drug during pregnancy can be assigned only when the intended benefits to the mother outweighs the potential risk to the fetus. During lactation prescribe define equipoise is not recommended.

Dosage and administration : A single dose for adults is 50-200 mg (average 100 mg, maximum dose – 400 mg per day) for children – 1.5 mg / kg (maximum 100 mg, maximum dose – 5 mg / kg per day). Ingested orally, 2 times a day after meals, washed down with water.

Side effects : From the digestive system: increased activity of “liver” transaminases, epigastric pain, ulceration of the gastrointestinal mucosa, diarrhea, heartburn, nausea, vomiting (rarely). On the part of the central nervous system: headache, dizziness, drowsiness. With hand mochevydelitelnoy system (rare):hematuria, oliguria, fluid retention, edema. blood system: thrombocytopenia, leukopenia, anemia, agranulocytosis, prolongation of bleeding time. Allergic reactions: skin rash, urticaria, anaphylactic shock.

 

Overdose : An overdose of the drug has not been described. There may be nausea and vomiting. For the treatment it is recommended gastric lavage, the appointment of adsorbents, infusion therapy, osmotic diuretics and symptomatic agents.

Interaction with other drugs : define equipoise is displaced from its association with proteins acetylsalicylic acid, which increases the plasma concentration of free define equipoise in 2-3 times. The competition for protein binding is also possible with a combination of define equipoise with oral hypoglycemic agents (tolbutamide), other sulfonamides, hydantoin, drugs digitalis (digoxin), cyclosporine, methotrexate. With simultaneous use of anticoagulants may increase their activities. When combined with a lithium salt of define equipoise increases their concentration in the blood plasma.

Cautions : define equipoise should be used with caution and in reduced dosages in patients with chronic renal failure and other diseases of the kidneys, reduced liver function, gastric ulcer or duodenal ulcer history, systemic lupus erythematosus, chronic heart failure, diuretics, anticoagulants, as well as in elderly patients. In the appointment of define equipoise in patients with intolerance to other NSAIDs can be an allergy. Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo.

equipoise cycle

Combined medication. It has a diuretic and hypotensive effect. Contains equipoise cycle – a thiazide diuretic, diuretic effect which is associated with impaired reabsorption of sodium, chlorine, potassium, magnesium, water in the distal nephron: delays the excretion of calcium, uric acid. It has antihypertensive properties;hypotensive action develops due to the expansion of the arterioles. It has no effect on normal blood pressure. The diuretic effect of equipoise cycle occurs within 1-2 hours, reaches a peak after 4 hours and lasts 6-12 hours. The antihypertensive effect occurs within 3-4 days, but in order to achieve optimal therapeutic effect may require 3-4 weeks. Triamterene – potassium-sparing diuretic, reduces the permeability of cell membranes of distal tubules to sodium ions and increases their excretion in the urine without increasing the excretion of potassium ions. The secretion of potassium ions in the distal tubule decreases. In combination with equipoise cycle triamterene can reduce hypokalemia caused by thiazide diuretics and enhance the diuretic effect of equipoise cycle. Diuretic action triamterena after ingestion observed after 15-20 minutes. The maximum effect – in 2-3 hours, duration -12 hours.

The pharmacokinetics of equipoise cycle is absorbed from the gastrointestinal tract is incomplete (60-80% of an oral dose), but pretty quickly.Communication with plasma proteins – 40%, the apparent distribution volume – 4.3 l / kg. equipoise cycle Maximum concentration in blood plasma of 2 ug / ml. The half-life – about 3-4 hours. equipoise cycle is not subject to significant metabolism. The primary way its elimination is renal excretion (filtration and secretion) unchanged drug. equipoise cycle crosses the placental barrier. Triamterene quickly, but not completely (30-70%) of the dose absorbed from the gastrointestinal tract. Moderate (67%) bound to plasma proteins. Maximum plasma concentration is achieved after 2-4 h. Bio transformed in the liver to form both active and inactive metabolites. The half-life of the drug normally is 1.5-2 h (anuria -10 h), metabolites -. 12 hours main route of elimination triamterena bile and feces, the secondary – the kidneys.

Indications

  • edematous syndrome of different genesis (chronic heart failure, nephrotic syndrome, cirrhosis);
  • arterial hypertension.

Contraindications:
Hypersensitivity to the drug (including to sulfonamides), chronic renal failure, anuria, acute glomerulonephritis, severe hepatic insufficiency, precoma, hepatic coma, hyperkalemia, lactation, age 18 years (effectiveness and safety have been established), I trimester of pregnancy.
with care – diabetes, gout, patients with impaired liver and / or kidney disease, folic acid deficiency (in patients with cirrhosis of the liver).

Dosage and administration.
Inside, not liquid, squeezed small amounts of water after eating. When edema initial dose is determined by the severity of violations of water-electrolyte metabolism and is usually 1 tablet 2 times a day after meals, then the dose may be increased to a maximum daily (3 tablets a day): 2 tablets after breakfast and 1 tablet after lunch. If compensation of swelling switching to maintenance therapy 1-2 tablets after 1 -2 days.
When hypertension – an initial dose of 1 tablet per day (in the morning, after breakfast), then gradually increase the dose. The maximum daily dose – 4 tablets. In patients with impaired renal function (creatinine clearance -. 30-50 ml / min) the maximum daily dose -1 tablet.

Side effects.
Fatigue, muscle weakness, cramps, palpitations, marked reduction of blood pressure, rarely thrombosis, embolism, increased urea, nephrolithiasis, dry mouth, thirst, pain or discomfort in the epigastric region, nausea, vomiting, abdominal pain, spastic nature , constipation, diarrhea, jaundice, hemorrhagic pancreatitis, acute cholecystitis, an increase of myopia, hyponatremia, hypomagnesemia, hyposalemia, hypo- or hyperkalemia, hypercalcemia, hyperuricemia, gout exacerbation, hypertriglyceridemia, impaired glucose tolerance, hyperglycemia, sometimes anemia, allergic reactions: redness skin, itching, hives.

Overdose. Symptoms : marked reduction of blood pressure. Treatment : symptomatic.

Interaction with other drugs.
Drugs extensively bind to proteins of blood (indirect anticoagulants, clofibrate, non-steroidal anti-inflammatory drugs) increase the diuretic effect of the drug.
The hypotensive effect reinforce vasodilators, barbiturates, phenothiazines, tricyclic antidepressants, ethanol.
Apo-triazido enhances neurotoxicity equipoise cycle salicylates, reduces the effect of oral hypoglycemic drugs, norepinephrine, epinephrine and protivopodagricakih funds, it enhances the effects (including spin), cardiac glycosides, cardiotoxic and neyrotokeicheskoe action lithium curariform effects of muscle relaxants, reduces excretion of quinidine. At the same time taking methyldopa increased risk of hemolysis.Cholestyramine reduces absorption of Apo-triazido.
Hlorpropamid while admission to Apo-triazido may cause severe hypokalemia.
In combination with non-steroidal anti-inflammatory drugs may develop acute renal failure.

Specific guidance
Prolonged use of Apo-triazido necessary to monitor blood levels of potassium ions, sodium, chloride, urea, creatinine, glucose, uric acid, peripheral blood (suspected folate deficiency).
At the start of treatment to avoid potentially hazardous activities that require increased attention and psychomotor speed reactions (due to lower blood pressure – slowing of psychomotor reactions). Do not take two doses at the same time, if the drug has been omitted.

Release form for filling and hospitals : In 1000 tablets in bottles of high density polyethylene (HDPE) white paper sealed with laminate floors, plastic screw cap. In the case of packing of the Russian enterprises : 50 tablets in bottles LDPE. Tablets on top put the swab of cotton wool Medical absorbent or polymer shock absorbers. 1 bottle with equipoise cycle instruction on the medical application in a cardboard box. 10 tablets in blisters of PVC foil and aluminum foil; 5 contour cell packages with instruction on the medical application in a cardboard box. online anabolic steroids pharmacy

bradley martyn steroids

anabolic steroids buy online

clinical equipoise

Aperomid ® is bischetvertichnym ammonium compounds of steroid structure, non-depolarizing muscle relaxant. Competitive blocking N-cholinergic receptors of the skeletal muscles, preventing the acetylcholine-induced depolarization of the end plate and the excitation of the muscle fiber.

Neuromuscular blockade reached within 5.5-6 minutes after administration of a single dose of 50 mg / kg and 5.3 min – a dose of 70-85 mg / kg. Carrying intubation possible within 2.5-3 minutes after administration of 70-100 mg / kg; using at the time to reach miorelaxation dose level sufficient for intubation lengthened. Duration of the effect is dependent on dose and type of anesthesia. When using the recommended dosages effective relaxation of skeletal muscles is maintained for 50-70 minutes.

In moderate doses does not cause significant changes in the cardiovascular system; in large doses it has ganglioblokiruyuschimi weak, M-anticholinergic activity.

Pharmacokinetics

The volume of distribution – 0.25 l / kg in renal failure – 0.37 l / kg. To a small extent crosses the placental barrier. The half-life – 1.7 hours (0.9-2.7 hours) in renal failure -. 4 hours (2-8,2 hours)
is metabolized in the tissues with the formation of the active metabolite (40-50% of the activity pipekuroniya clinical equipoise) and inactive derivatives.
excreted by the kidneys unchanged to 75%, the rest is in the form of metabolites. Clearance – 0.12-0.15 l / kg / h in renal impairment – 0.08 l / kg / h.

Indications

The relaxation of skeletal muscles and to facilitate endotracheal intubation during operations and diagnostic procedures in a ventilator.

Contraindications

Hypersensitivity. Age up to 3 months (dose in children under the age of 3 months to be determined).

Carefully

Obstruction of the biliary tract, edema syndrome, increased blood volume, or dehydration, disruption of water and electrolyte metabolism, hypothermia, myasthenia gravis, myasthenic syndrome, respiratory depression, kidney / liver failure, decompensated chronic heart failure, children’s age (14 years).

Pregnancy and lactation

Experience sufficient to prove the safety pipekuroniya clinical equipoise for pregnant women and fetus, there is no.
In the case of general anesthesia for cesarean section pipekuroniya clinical equipoise does not change the index of Apgar, muscle tone and cardiovascular adaptation neonatal.
Data on the use of pipekuroniya clinical equipoise during lactation are not available.

Dosing and Administration

Only intravenously!
Immediately before administration the contents of the vial is diluted with water for injection or 0.9% sodium chloride solution.

Adults and children from 14 years and above for the complete muscle relaxation is administered 70-80 mg / kg. The maximum single dose – 100 mg / kg. To maintain muscle relaxation in a long time to be administered repeatedly at doses of 15% of the original (10-15 mg / kg). During the intubation, suxamethonium on the background of the initial dose -40-50 mg / kg.

In chronic renal failure value of the dose administered is determined by the values of creatinine clearance (CC): QA below 100 ml / min administered 85 mg / kg, QC below 80 ml / min – 70 g / kg, QC below 60 ml / min – 55 ug / kg, while RC least 40 ml / min – 50 g / kg.

The doses in children aged 3 months to 12 months – 40 mg / kg (provides muscle relaxation lasting 10 to 44 minutes); from 1 year to 14 years – 57 mg / kg (muscle relaxation – from 18 to 52 min.)

Side effect

From the musculoskeletal system: the weakness of the skeletal muscles after the cessation of muscle relaxation, muscle atrophy.

From the nervous system: central nervous system depression, hypoesthesia.

The respiratory system: respiratory depression, hypopnea, apnea, muscle relaxation after cessation, pulmonary atelectasis, laryngospasm.

Since the cardiovascular system: bradycardia, decreased blood pressure; myocardial ischemia (up to the development of myocardial infarction) and brain, atrial fibrillation, ventricular arrythmia.

From the side of hematopoiesis and hemostasis system: decrease in partial thromboplastin time, prothrombin and thrombosis.

From the urinary system: anuria.

Laboratory findings: hypercreatininemia, hypoglycemia, hyperkalemia.

Allergic reactions: skin rash, urticaria.

Overdose

Symptoms: prolonged paralysis of skeletal muscles, and sleep apnea, marked reduction in blood pressure, shock.
Treatment: neostigmine 1-3 mg in combination with atropine 0.5-1.25 mg or 10-30 mg of galantamine (against the background of continued mechanical ventilation).

Interaction with other drugs

Means for inhalation (halothane, methoxyflurane, diethyl ether) and intravenous general anesthesia (ketamine, fentanyl, propanidid, barbiturates) depolarizing and non-depolarizing muscle relaxants, antibiotics (aminoglycosides, tetracyclines), imidazole and metronidazole, antifungals (amphotericin B), diuretics, beta-blockers, thiamine, MAO inhibitors, guanethidine, protamine, phenytoin, alpha-blockers, blockers “slow” calcium channels, for intravenous use lidocaine enhance and / or prolong the action.

Drugs that reduce the concentration of K + in the blood aggravate respiratory depression (until it stops).
Opioid analgesics increase respiratory depression.

When applying to a surgical intervention glucocorticosteroids, neostigmine, epinephrine, theophylline, potassium chloride, sodium chloride, ammonium chloride, calcium effect may weaken.

Depolarizing muscle relaxants can both strengthen and weaken the action pipekuroniya clinical equipoise (depending on the dose, application time and individual sensitivity).

In an application with quinidine, magnesium salts, procainamide may increase the severity of muscle relaxation.

Because of the possible precipitation should not be mixed with other pipekuroniya clinical equipoise solution for injection or infusion. The exception is 0.9% sodium chloride solution, 5% dextrose solution and Ringer’s solution.

special instructions

Apply only under the supervision of an experienced anesthesiologist, in the presence of conditions for intubation, mechanical ventilation, oxygen therapy.

Careful monitoring during surgery and in the early postoperative period in order to maintain vital functions to the full restoration of adequate vitality.

In calculating the dosage should be considered a technique applied anesthesia, possible interactions with drugs administered before or during anesthesia, the patient’s condition and sensitivity.

Patients with disorders of neuromuscular transmission, obesity, renal failure, liver disease and biliary tract, with indications of a history of myocardial polio should be prescribed the drug in smaller doses.Some states (hypokalemia, digitalization, gipermagniemiya, hypocalcemia, hypoproteinemia, dehydration, acidosis, hypercapnia, cachexia, hypothermia) may contribute to lengthening or enhancing effect.
Before the start of anesthesia should be carried out correction of electrolyte balance, acid-base balance and correct dehydration.

Pregnant women, who for the treatment of toxemia took magnesium salt (capable of enhancing neuromuscular blockade) pipekuroniya clinical equipoise is administered in small doses.
Efficacy and safety of use in the neonatal period have not been studied.
The therapeutic effect in infants from 3 months to 1 year is virtually identical from that of adults.
children aged 1 year to 14 years are less sensitive to pipekuroniya clinical equipoise and duration of the therapeutic effect they are shorter than in adults and infants (under 1 year).

Effects on ability to drive and use machinery

Within 24 hours after the full recovery of neuromuscular conduction is not recommended to transport and deal with potentially dangerous in terms of injury prevention activities.

release Form

Valium for drug of a solution for intravenous administration of 4 mg vials with a capacity of 2 ml with ring or point of fracture.
1 or 5 vials in blisters.
1 blisters 1 ampoule or 1, 2 or 5 contour cell packages of 5 ampoules together with instructions for use in paper cartons. steriods for sale

equipoise definition

The combined medicament for topical use on the basis of highly purified bee venom. Beer poison has analgesic and anti-inflammatory action (stabilizes lysosomal membranes) exhibits antibacterial effect (inhibits growth of gram-positive bacteria). equipoise definition salicylate refers to a group of non-steroidal anti-inflammatory agents, has a strong anti-inflammatory action ( inhibits the production of prostaglandins, inhibits cyclooxygenase). allyl isothiocyanate (purified standardized extract of mustard oil) causes deep heating of tissues, improves local blood flow, reduces the tonic contraction of muscle.

Indications

  • peripheral nervous system diseases, accompanied by a sensation of pain: neuralgia, neuritis, radiculitis, pain in the lumbar region (sciatica);
  • muscle pain (myalgia) and soft tissue in the t h due to injury..;
  • warming up the muscles before, during and after physical activity and sports;
  • Damage / tendon strains, accompanied by pain and swelling;
  • diseases of the musculoskeletal system (osteoarthritis, rheumatic soft tissue disease), degenerative-dystrophic lesions and joint pain.

Contraindications
: Hypersensitivity to bee venom, salicylates, isothiocyanate; severe chronic renal failure; liver failure; skin diseases; neoplasms; skin lesions; acute arthritis; infectious diseases; inhibition of bone marrow hematopoiesis; mental illness; children’s age (up to 6 years); pregnancy and lactation.

Precautions
Kidney failure, children from 6 to 12 years.

Dosage and administration:
Outwardly.
A strip of ointment the length of 3 – 5 cm evenly on the skin (thickness of about 1 mm) until the redness and heat sensation (2-3 minutes). Thereafter rub the ointment into the skin rapidly and slowly. To enhance the therapeutic effect it is recommended to maintain treated to a warm location. Apply 2-3 times a day until the disappearance of symptoms (no more than 10 days).

Side effects:
In rare cases, allergic skin reactions, irritation at the site of application.

Interaction with other medicinal products
equipoise definition salicylate increases the effect of anticoagulants, methotrexate.

Special instructions:
In renal insufficiency should avoid prolonged use on large surfaces. Do not apply to broken or irritated skin. Avoid contact with eyes, ointments, mucous membranes and open wounds. After applying the ointment, wash your hands with soap and water. steroider kob

equipoise

Aperomid ® is bischetvertichnym ammonium compounds of steroid structure, non-depolarizing muscle relaxant. Competitive blocking N-cholinergic receptors of the skeletal muscles, preventing the acetylcholine-induced depolarization of the end plate and the excitation of the muscle fiber.

Neuromuscular blockade reached within 5.5-6 minutes after administration of a single dose of 50 mg / kg and 5.3 min – a dose of 70-85 mg / kg. Carrying intubation possible within 2.5-3 minutes after administration of 70-100 mg / kg; using at the time to reach miorelaxation dose level sufficient for intubation lengthened. Duration of the effect is dependent on dose and type of anesthesia. When using the recommended dosages effective relaxation of skeletal muscles is maintained for 50-70 minutes.

In moderate doses does not cause significant changes in the cardiovascular system; in large doses it has ganglioblokiruyuschimi weak, M-anticholinergic activity.

Pharmacokinetics

The volume of distribution – 0.25 l / kg in renal failure – 0.37 l / kg. To a small extent crosses the placental barrier. The half-life – 1.7 hours (0.9-2.7 hours) in renal failure -. 4 hours (2-8,2 hours)
is metabolized in the tissues with the formation of the active metabolite (40-50% of the activity pipekuroniya equipoise) and inactive derivatives.
excreted by the kidneys unchanged to 75%, the rest is in the form of metabolites. Clearance – 0.12-0.15 l / kg / h in renal impairment – 0.08 l / kg / h.

Indications

The relaxation of skeletal muscles and to facilitate endotracheal intubation during operations and diagnostic procedures in a ventilator.

Contraindications

Hypersensitivity. Age up to 3 months (dose in children under the age of 3 months to be determined).

Carefully

Obstruction of the biliary tract, edema syndrome, increased blood volume, or dehydration, disruption of water and electrolyte metabolism, hypothermia, myasthenia gravis, myasthenic syndrome, respiratory depression, kidney / liver failure, decompensated chronic heart failure, children’s age (14 years).

Pregnancy and lactation

Experience sufficient to prove the safety pipekuroniya equipoise for pregnant women and fetus, there is no.
In the case of general anesthesia for cesarean section pipekuroniya equipoise does not change the index of Apgar, muscle tone and cardiovascular adaptation neonatal.
Data on the use of pipekuroniya equipoise during lactation are not available.

Dosing and Administration

Only intravenously!
Immediately before administration the contents of the vial is diluted with water for injection or 0.9% sodium chloride solution.

Adults and children from 14 years and above for the complete muscle relaxation is administered 70-80 mg / kg. The maximum single dose – 100 mg / kg. To maintain muscle relaxation in a long time to be administered repeatedly at doses of 15% of the original (10-15 mg / kg). During the intubation, suxamethonium on the background of the initial dose -40-50 mg / kg.

In chronic renal failure value of the dose administered is determined by the values of creatinine clearance (CC): QA below 100 ml / min administered 85 mg / kg, QC below 80 ml / min – 70 g / kg, QC below 60 ml / min – 55 ug / kg, while RC least 40 ml / min – 50 g / kg.

The doses in children aged 3 months to 12 months – 40 mg / kg (provides muscle relaxation lasting 10 to 44 minutes); from 1 year to 14 years – 57 mg / kg (muscle relaxation – from 18 to 52 min.)

Side effect

From the musculoskeletal system: the weakness of the skeletal muscles after the cessation of muscle relaxation, muscle atrophy.

From the nervous system: central nervous system depression, hypoesthesia.

The respiratory system: respiratory depression, hypopnea, apnea, muscle relaxation after cessation, pulmonary atelectasis, laryngospasm.

Since the cardiovascular system: bradycardia, decreased blood pressure; myocardial ischemia (up to the development of myocardial infarction) and brain, atrial fibrillation, ventricular arrythmia.

From the side of hematopoiesis and hemostasis system: decrease in partial thromboplastin time, prothrombin and thrombosis.

From the urinary system: anuria.

Laboratory findings: hypercreatininemia, hypoglycemia, hyperkalemia.

Allergic reactions: skin rash, urticaria.

Overdose

Symptoms: prolonged paralysis of skeletal muscles, and sleep apnea, marked reduction in blood pressure, shock.
Treatment: neostigmine 1-3 mg in combination with atropine 0.5-1.25 mg or 10-30 mg of galantamine (against the background of continued mechanical ventilation).

Interaction with other drugs

Means for inhalation (halothane, methoxyflurane, diethyl ether) and intravenous general anesthesia (ketamine, fentanyl, propanidid, barbiturates) depolarizing and non-depolarizing muscle relaxants, antibiotics (aminoglycosides, tetracyclines), imidazole and metronidazole, antifungals (amphotericin B), diuretics, beta-blockers, thiamine, MAO inhibitors, guanethidine, protamine, phenytoin, alpha-blockers, blockers “slow” calcium channels, for intravenous use lidocaine enhance and / or prolong the action.

Drugs that reduce the concentration of K + in the blood aggravate respiratory depression (until it stops).
Opioid analgesics increase respiratory depression.

When applying to a surgical intervention glucocorticosteroids, neostigmine, epinephrine, theophylline, potassium chloride, sodium chloride, ammonium chloride, calcium effect may weaken.

Depolarizing muscle relaxants can both strengthen and weaken the action pipekuroniya equipoise (depending on the dose, application time and individual sensitivity).

In an application with quinidine, magnesium salts, procainamide may increase the severity of muscle relaxation.

Because of the possible precipitation should not be mixed with other pipekuroniya equipoise solution for injection or infusion. The exception is 0.9% sodium chloride solution, 5% dextrose solution and Ringer’s solution.

special instructions

Apply only under the supervision of an experienced anesthesiologist, in the presence of conditions for intubation, mechanical ventilation, oxygen therapy.

Careful monitoring during surgery and in the early postoperative period in order to maintain vital functions to the full restoration of adequate vitality.

In calculating the dosage should be considered a technique applied anesthesia, possible interactions with drugs administered before or during anesthesia, the patient’s condition and sensitivity.

Patients with disorders of neuromuscular transmission, obesity, renal failure, liver disease and biliary tract, with indications of a history of myocardial polio should be prescribed the drug in smaller doses.Some states (hypokalemia, digitalization, gipermagniemiya, hypocalcemia, hypoproteinemia, dehydration, acidosis, hypercapnia, cachexia, hypothermia) may contribute to lengthening or enhancing effect.
Before the start of anesthesia should be carried out correction of electrolyte balance, acid-base balance and correct dehydration.

Pregnant women, who for the treatment of toxemia took magnesium salt (capable of enhancing neuromuscular blockade) pipekuroniya equipoise is administered in small doses.
Efficacy and safety of use in the neonatal period have not been studied.
The therapeutic effect in infants from 3 months to 1 year is virtually identical from that of adults.
children aged 1 year to 14 years are less sensitive to pipekuroniya equipoise and duration of the therapeutic effect they are shorter than in adults and infants (under 1 year).

Effects on ability to drive and use machinery

Within 24 hours after the full recovery of neuromuscular conduction is not recommended to transport and deal with potentially dangerous in terms of injury prevention activities.

release Form

Valium for drug of a solution for intravenous administration of 4 mg vials with a capacity of 2 ml with ring or point of fracture.
1 or 5 vials in blisters.
1 blisters 1 ampoule or 1, 2 or 5 contour cell packages of 5 ampoules together with instructions for use in paper cartons.

where to buy hgh online

buy getropin

buy hgh china